The phosphate salt of codeine occurs as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and a little bit soluble in Alcoholic beverages. The molecular excess weight is 406.37. Its molecular system is C18H21NO3•H3PO4 • ½ H2O, and it has the following chemical framework.
Possibility Summary As a result of likely for severe adverse reactions, together with surplus sedation, respiratory despair, and Loss of life in the breastfed toddler, suggest patients that breastfeeding is just not advised for the duration of cure with Promethazine with Codeine Oral Alternative [see Warnings and Safeguards ( five.
The concomitant use of anticholinergic medication with Promethazine with Codeine Oral Solution may increase hazard of urinary retention and/or critical constipation, which may result in paralytic ileus [seeWARNINGS AND Safety measures (five.
If your affected person develops these symptoms or signs and symptoms, elevate the dose towards the prior degree and taper a lot more gradually, both by growing the interval between decreases, decreasing the amount of modify in dose, or both of those.
Most MAO inhibitors must also not be taken for 2 months right before therapy with this medication. Ask your health care provider when to start or halt having this medication.
It's not a whole list of doable Uncomfortable side effects. When you discover other side effects not detailed higher than, Get hold of your health care provider or pharmacist.
Data Human Facts Revealed information from circumstance Management and observational scientific tests on codeine use during pregnancy are inconsistent inside their conclusions. Some scientific studies of codeine exposure confirmed an increased hazard of Total congenital malformations while some did not.
Do not forget that this medication has actually been prescribed because your doctor has judged that the reward to you is bigger than the risk of Uncomfortable side effects. Many of us working with this medication would not have significant Unwanted side effects.
If adrenal insufficiency is diagnosed, take care of with physiologic substitute doses of corticosteroids. Wean the client off of the opioid to allow adrenal function to Get better and proceed corticosteroid treatment method until eventually adrenal function recovers. Other opioids may very well be attempted as some circumstances reported usage of a different opioid without recurrence of adrenal insufficiency. The information obtainable won't identify any particular opioids as remaining much more prone to be associated with adrenal insufficiency.
Propulsive peristaltic waves while in the colon are lowered, whilst tone might be amplified to the point of get more info spasm causing constipation. Other opioid-induced consequences may well include a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.
Hire other supportive steps (together with oxygen and vasopressors) in the administration of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias would require Innovative life-support techniques. Gastric emptying may be useful in removing unabsorbed drug.
Will not retain leftover medication. Only one dose could potentially cause death in someone using this medication accidentally or improperly. Read and punctiliously Adhere to the Recommendations presented with this medicine about how to properly eliminate any unused part.
The Promethazine VC with Codeine brand name name has been discontinued in the U.S. If generic versions of the item have already been permitted via the FDA, there might be generic equivalents out there.
Read through the Medication Guidebook provided by your pharmacist Before you begin getting codeine/promethazine and each time you get a refill. When you've got any issues, question your medical doctor or pharmacist.